Effects of L-NG-Monomethyl-Arginine on Apoptosis of Articular Chondrocytes

We aimed to investigate the effects of L-NG-monomethyl-arginine on apoptosis articular chondrocytes. 30 rabbits were randomly divided into six groups (n=5). The pathological changes detected by Hematoxylin and Eosin staining. expression levels synovial fluid serum nitric oxide measured. chondrocytes was tested using terminal deoxynucleotidyl transferase dUTP nick end labeling assay. reconstituted B-cell lymphoma-2 human associated X protein in cartilage tissues immunohistochemical Mankin score model group significantly higher than that control (p<0.01). scores decreased treatment (p<0.05). protein, rate index chondrocytes, those markedly However, similar (p>0.05). With increasing dose, level lymphoma-2/B-cell ratio elevated reduced expressions oxide, raised ratio, thereby inhibiting chondrocyte apoptosis.